Urinary endocrine analyses and their application to assess menstrual cycle function in populations exposed to potential hazards.
Am J Epidemiol 2007 Jun; 165(11)(Suppl):S41
The challenge of assessing the relationship between toxic exposures and reproductive well-being of women is heightened by two factors: the everexpanding number and variety of potentially hazardous agents (chemical and otherwise) in the workplace and environment; and evaluating the inaccessible female reproductive system with its complex menstrual cycle. Advances in sensitive and specific immunoassays to measure the primary female reproductive hormones or their metabolites in urine have greatly facilitated the capabilities to assess the hypothalamo-hypophysial-ovarian axis as it relates to menstrual cycle function in populations of women who may not be highly motivated. However, various immunoassays draw on different analytical strategies to quantify their analytes; these differences and what is being measured are issues to be considered when applying these tools to field studies. These analytical methods, the measurements they yield, and their attendant algorithms for deriving endpoints for statistical analyses are being applied to a variety of population studies to better understand the characteristics of the menstrual cycle, and how its function is affected by external factors including potentially hazardous exposures. The discussion will include an overview of the toxicity of selected pesticides and polyhalogenated biphenyls on female reproductive potential, insights into the effects of these exposures on menstrual cycle function derived from population studies employing urinary endocrine biological measurements, and descriptions of ongoing studies designed to further understand these relationships.
Health-hazards; Environmental-hazards; Environmental-factors; Environmental-exposure; Urine-chemistry; Women; Menstrual-disorders; Mathematical-models; Analytical-chemistry; Analytical-methods; Toxicopathology; Toxicology; Toxic-effects; Urogenital-system; Urogenital-system-disorders; Uterus; Reproductive-hazards; Reproductive-effects; Reproduction; Reproductive-system-disorders; Work-environment; Worker-health; Workplace-studies; Statistical-analysis
Agriculture, Forestry and Fishing; Mining
American Journal of Epidemiology. Abstracts of the 40th Annual Meeting Society for Epidemiologic Research Boston, Massachusetts, June 19-22, 2007