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Evaluation of the contact and respiratory sensitization potential of volatile organic compounds generated by simulated indoor air chemistry.

Authors
Anderson-SE; Wells-JR; Fedorowicz-A; Butterworth-LF; Meade-BJ; Munson-AE
Source
Toxicol Sci 2007 Jun; 97(2):355-363
NIOSHTIC No.
20032117
Abstract
Up to 60 million people working indoors experience symptoms such as eye, nose and throat irritation, headache, and fatigue. Investigations into these complaints have ascribed the effects to volatile organic compounds (VOCs) emitted from building materials, cleaning formulations, or other consumer products. New compounds can result when the VOCs react with hydroxyl or nitrate radicals or ozone present in indoor environments. Several oxygenated organic compounds, such as glyoxal, methylglyoxal, glycolaldehyde, and diacetyl, have been identified as possible reaction products of indoor environment chemistry. Although research has previously identified diacetyl and glyoxal as sensitizers, additional experiments were conducted in these studies to further classify their sensitization potential. Sensitization potential of these four compounds was assessed using quantitative structure-activity relationship (QSAR) programs. Derek for Windows and National Institute for Occupational Safety and Health logistic regression predicted all compounds to be sensitizers, while TOPKAT 6.2 predicted all compounds except for methylglyoxal. All compounds were tested in a combined irritancy and local lymph node assay (LLNA). All compounds except for glyoxal were found to be irritants and all tested positive in the LLNA with EC3 values ranging from 0.42 to 1.9%. Methylglyoxal significantly increased both the B220+ and IgE+B220+ cell populations in the draining lymph nodes and total serum IgE levels. The four compounds generated by indoor air chemistry were predicted by QSAR and animal modeling to be sensitizers, with the potential for methylglyoxal to induce IgE. The identification of these compounds as sensitizers may help to explain some of the health effects associated with indoor air complaints.
Keywords
Indoor-air-pollution; Volatiles; Organic-compounds; Construction-materials; Respiratory-system-disorders; Sensitization; Hypersensitivity; Chemical-hypersensitivity; Cleaning-compounds; Occupational-exposure; Hydroxyl-groups; Nitrates; Chemical-structure; Mathematical-models; Lymph-nodes; Indoor-environmental-quality
Contact
National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
TOSCF2
CAS No.
10028-15-6; 107-22-2; 431-03-8; 78-98-8
Publication Date
20070601
Document Type
Journal Article
Email Address
sanderson4@cdc.gov
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1096-6080
NIOSH Division
OD; HELD
Source Name
Toxicological Sciences
State
WV
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