Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Exposure to the immunosuppresant, perfluorooctanoic acid, enhances the murine IgE and airway hyperreactivity response to ovalbumin.

Authors
Fairley-KJ; Purdy-R; Kearns-S; Anderson-SE; Meade-BJ
Source
Toxicol Sci 2007 Jun; 97(2):375-383
NIOSHTIC No.
20032107
Abstract
These studies were conducted to investigate the role of dermal exposure to perfluorooctanoic acid (PFOA), a known immunosuppressant, on the hypersensitivity response to ovalbumin (OVA) in a murine model of asthma. PFOA has had widespread use as a carpet and fabric protectant. BALB/c mice were exposed dermally, on the dorsal surface of each ear, to concentrations of PFOA ranging from 0.01 to 1.5% (applied dose 0.25-50 mg/kg) for 4 days. In hypersensitivity studies, mice were also ip injected with 7.5 g OVA and 2 mg alum on days 1 and 10 and in some studies challenged with 250 g OVA by pharyngeal aspiration on days 17 and 26. Following exposure to PFOA, an increase in liver weights and a decrease in thymus and spleen weights and cellularities were observed. Similar immunomodulatory trends were demonstrated in mice coadministered PFOA and OVA. Compared to the OVA alone-exposed animals, an increase in total IgE was demonstrated when mice were coexposed to OVA and concentrations of PFOA ranging from 0.75 to 1.5%, while the OVA-specific IgE response peaked with 0.75% PFOA coexposure (p less than or equal to 0.05). OVA-specific airway hyperreactivity was increased in the 1.0% PFOA coexposed group (p less than or equal to 0.05), with an increased pleiotropic cell response characterized by eosinophilia and mucin production, in animals coexposed to concentrations of PFOA up to 1.0%, as compared to the OVA alone-exposed animals. In a murine model, PFOA was demonstrated to be immunotoxic following dermal exposure, with an enhancement of the hypersensitivity response to OVA, suggesting that PFOA exposure may augment the IgE response to environmental allergens.
Keywords
Toxic-effects; Allergic-reactions; Immune-reaction; Immune-system; Hypersensitivity; Animal-studies; Exposure-levels; Dose-response; Cellular-reactions; Acids; Laboratory-animals; Models; Immunotoxins; Allergens
Contact
National Institute for Occupational Safety and Health, MS 4020, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
TOSCF2
CAS No.
335-67-1
Publication Date
20070601
Document Type
Journal Article
Email Address
bhm8@cdc.gov
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1096-6080
NIOSH Division
OD
Source Name
Toxicological Sciences
State
WV; WI
TOP