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The importance of cytochrome P450 2B6 in the human metabolism of environmental chemicals.

Authors
Hodgson-E; Rose-RL
Source
Pharmacol Ther 2007 Feb; 113(2):420-428
NIOSHTIC No.
20032039
Abstract
Cytochrome P450 (CYP) 2B6 (CYP2B6) is a human CYP isoform found in variable amounts in the liver and other organs. It is known to be inducible and polymorphic and has a wide range of xenobiotic substrates. Studies of CYP2B6 to date have concentrated heavily on clinical drugs. In the present communication, however, we concentrate on its role in the metabolism of environmental xenobiotics. The term environment is used, in its broadest sense, to include natural ecosystems and agroecosystems as well as the industrial and indoor domestic environments. In essence, this excludes only clinical drugs and drugs of abuse. Many of these chemicals, including agrochemicals and industrial chemicals, can serve as substrates, inhibitors and/or inducers of CYP2B6, these activities being often modified by the existence of polymorphic variants. Metabolism-based interactions between environmental chemicals are discussed, as well as the emerging possibility of metabolic interactions between environmental chemicals and clinical drugs.
Keywords
Agricultural-industry; Agricultural-chemicals; Pesticides-and-agricultural-chemicals; Humans; Fertility; Metabolic-disorders; Metabolic-rate; Metabolic-study; Environmental-exposure; Chemical-properties; Agriculture; Work-environment; Clinical-chemistry; Ecological-systems
Contact
Department of Environmental and Molecular Toxicology, North Carolina State University, PO Box 7633, Raleigh, NC 27695
CODEN
PHTHDT
CAS No.
1563-66-2
Publication Date
20070201
Document Type
Journal Article
Email Address
ernest_hodgson@ncsu.edu
Funding Type
Cooperative Agreement
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007551
Issue of Publication
2
ISSN
0163-7258
Source Name
Pharmacology & Therapeutics
State
MD; NC
Performing Organization
East Carolina University
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