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Custom made pani fiber to assess dermal partitioning and absorption of biocides.

Authors
Yeatts-JL; Baynes-RE; Riviere-JE
Source
Toxicologist 2007 Mar; 96(1):433
NIOSHTIC No.
20031941
Abstract
A custom-made polyaniline (PANI) coated metal alloy fiber was evaluated for its use in assessing dermal partitioning and absorption of certain biocides. This PANI coating provides a unique functionality compared to three commercially available fibers polyacrylate (PA), polydimethylsiloxane (PDMS), and Carbowax/templated resin. The production of this custom-made fiber is a relatively simple process that can be controlled by utilizing cyclic voltammetry (CV). The CV program for coating the metal alloy fiber consisted of one initial scan from -0.2V to +1.1V followed by several sets of scans from -0.2V to +0.8V with a 15 second equilibration time at -0.2V between scan sets and scan rate of 50 mV/sec. The electrolyte solution was 0.1M aniline in 1.0M sulfuric acid. The bare metal alloy fiber SPME assembly, commercially donated, served as the working electrode. In our experiments, cyclic voltammetry appeared to give more consistent results and control in coating the metal alloy fiber with PANI as opposed to using a constant deposition potential. To assess the PANI fiber, solid-phase microextraction (SPME) was performed by direct immersion into water solutions containing either a single component or a mixture of biocides at 37C and stir rate of 400 R.P.M. The PANI fiber was desorbed directly in the GC-MS injector port for 5 minutes at 200C following immersion. This PANI coated fiber exhibited good reproducibility and durability. The RSD's averaged 6 to 9% over a period of three days for the first 46 injections of a single component (5ppm 2-phenylphenol) in water with only three outliers. Time profile experiments revealed that both p-chloro-o-cresol and o-phenylphenol reached equilibrium before 10 minutes while the equilibrium time for o-benzyl-p-chlorophenol was greater than 90 minutes.
Keywords
Chemical-properties; Chemical-composition; Filter-fabrics; Filter-materials; Filter-membranes; Filtration; Aqueous-solutions
CAS No.
7664-93-9
Publication Date
20070301
Document Type
Abstract
Funding Amount
875919
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003669
Issue of Publication
1
ISSN
1096-6080
Priority Area
Disease and Injury: Allergic and Irritant Dermatitis
Source Name
The Toxicologist. Society of Toxicology 46th Annual Meeting and ToxExpo, March 25-29, 2007, Charlotte, North Carolina
State
NC
Performing Organization
North Carolina State University, Raleigh, North Carolina
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