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(2-methoxyethoxy) acetic acid: a urinary biomarker of exposure to JP-8 jet fuel.

Authors
Butler-MA; B'Hymer-CB; Cheever-KL; Krieg-E; Toennis-CA; Clark-JC; Gibson-RL
Source
Toxicologist 2007 Mar; 96(1):85
NIOSHTIC No.
20031902
Abstract
(2-Methoxyethoxy)acetic acid (MEAA), the major urinary metabolite of the deicing agent 2-(2-methoxyethoxy)ethanol (diEGME) added to JP-8 jet fuel, was used to measure exposure to JP-8 in air force personnel at six airbases in the United States. JP-8 is a kerosene based fuel containing over 200 different compounds, including aliphatics, aromatics, benzene, and naphthalene, all of which vary in concentration depending upon the specific batch of JP-8. DiEGME is always present at 0.1 %. Post-shift urine specimens were obtained from personnel who performed fuel tank maintenance and their attendants (high category, n = 98), fuel handlers (moderate category, n = 38) and personnel with no direct JP-8 contact (low category, n = 61). Urine containing a deuterated (2-butoxy)acetic acid internal standard was extracted with ethyl acetate, followed by esterification to the ethyl ester. The ethyl ester was extracted with methylene chloride and concentrated. Quantitation was by a gas chromatograph equipped with a mass spectrometer. The mean urinary MEAA level was significantly greater in the high (6.9, SD = 15.5 g/ml) category, as compared to the means of the moderate (0.4, SD = 0.9 g/ml, p = 0.0024) and low (0.1, SD = 0.02 g/ml, p= 0.0002) categories. The maximum concentrations of urinary MEAA were 110.0 g/ml, 4.8 g/ml, and 0.2 g/ml and the percent of measurements below the limit of detection (0.1 ug/ml) were 6%, 67%, and 97% for the high, moderate, and low categories, respectively. This study demonstrated that urinary MEAA can be used a biomarker of exposure to JP-8.
Keywords
Cell-alteration; Cell-damage; Cellular-reactions; Cell-biology; Cell-function; Cell-metabolism; Cell-morphology; Cell-transformation; Epidemiology; Biomarkers; Gas-adsorption; Urinalysis; Urine-chemistry; Fuels; Jet-engine-fuels
CAS No.
16024-56-9; 111-77-3
Publication Date
20070301
Document Type
Abstract
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1096-6080
NIOSH Division
DART
Priority Area
Healthcare and Social Assistance; Manufacturing
Source Name
The Toxicologist. Society of Toxicology 46th Annual Meeting and ToxExpo, March 25-29, 2007, Charlotte, North Carolina
State
OH
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