Cytokine genotype and phenotype effects on lung function decline in firefighters.
Josyula-AB; Kurzius-Spencer-M; Littau-SR; Yucesoy-B; Fleming-J; Burgess-JL
J Occup Environ Med 2007 Mar; 49(3):282-288
Objective: We conducted this study to evaluate the association of cytokine genotypes and sputum concentrations on longitudinal decline in lung function in firefighters. Methods: In 67 firefighters with at least four pulmonary function tests, DNA was analyzed for functional polymorphisms of interleukin (IL)-1 beta, IL-1 receptor antagonist (IL-1RA), IL-8, IL-10, tumor necrosis factor-alpha (TNF-alpha) genes, and sputum evaluated for cytokine concentration by ELISA. Results: The annual rate of FEV1 decline was greater in firefighters with TT genotypes at IL-10 (-819) (P = 0.009) and with CT or TT genotypes at IL-1RA (2018) (P = 0.050). These genotypes were not associated with concentrations of sputum cytokine, but increased IL-1RA was associated with a slower rate of FEV1 decline (P = 0.025), as was increased sputum macrophage count (P = 0.002). Conclusions: Cytokine genotypes were associated with the rate of FEV1 decline but did not alter concentrations of sputum cytokine. Increased sputum IL-IRA may be protective.
Lung-disease; Lung-disorders; Particulate-dust; Pulmonary-disorders; Pulmonary-function; Pulmonary-system-disorders; Genes; Genetics; Genetic-factors; Fire-fighters; Fire-hazards; Respiratory-system-disorders
Jefferey L. Burgess, MD, MS, MPH, Division of Community, Environment and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona,1295 Martin Ave., Tucson, AZ 85724-5210
Journal of Occupational and Environmental Medicine