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Multiplexed analyses of serum antibodies to Bacillus anthracis toxins from cases with cutaneous anthrax in the former Soviet Republic of Kazakhstan.

Authors
Sammons-DL; Smith-JP; Biagini-RE; Snawder-JE; Striley-CAF; Robertson-SK; MacKenzie-BA; Wilkins-PP; Quinn-CP
Source
Abstr Pap - Am Chem Soc 2003 Sep; 226(Part 1):U90 044-AGRO
NIOSHTIC No.
20031843
Abstract
Bacillus anthracis (Ba) exotoxins, lethal factor (IF) and protective antigen (PA) are immunogenic, and exposure may be evaluated by measurement of specific antibodies by multiplexed fluorescence covalent microbead Immunoassay (FCMIA). Using sera from individuals with "confirmed" cutaneous cases of (N=7) of anthrax from the former Soviet Republic of Kazakhstan (Kaz) and 8 donor controls we found 47.9 +/- 37.4 and 19.0 +/- 16.3, 1.00 +/- 0.98 and 0.14 +/- 0.12 microg/ml anti-LF lgG and anli-PA IgG, respectively (Kaz and control; mean +/- Standard Deviation (SD]; both P<0.001). For anti-LF 19M and anti-PA 19M, we found 1107 +/- 999 and 265 +/- 174, 33.5 +/- 29.7 and 9.6 +/- 6.0 (Kaz and control; standard sera equivalent dilution +/- SD; P<0.001), respectively, These data Indicate that cutaneous anthrax Infection can induce significant levels of anti-LF and anti-PA IgG and IgM which can be measured by multiplexed FCMIA.
Keywords
Exposure-levels; Exposure-assessment; Blood-analysis; Antibody-response; Dermatitis; Skin-exposure; Skin-absorption; Serological-techniques; Bacteria; Bacterial-disease
Contact
Deborah L. Sammons, Biomonitorlng and Health Assessment Branch, CDC/NIOSH, 4676 Columbia Parkway, Mailstop C-26, Cincinnati, OH 45226,
CODEN
ACSRAL
Publication Date
20030901
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
dls7@cdc.gov
Fiscal Year
2003
NTIS Accession No.
NTIS Price
ISSN
0065-7727
NIOSH Division
DART
Source Name
Abstracts of Papers - American Chemical Society
State
OH; GA
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