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Silicon microfabricated column with microfabricated differential mobility spectrometer for GC analysis of volatile organic compounds.

Authors
Lambertus-GR; Fix-CS; Reidy-SM; Miller-RA; Wheeler-D; Nazarov-E; Sacks-R
Source
Anal Chem 2005 Dec; 77(23):7563-7571
NIOSHTIC No.
20031804
Abstract
A 3.0-m-long, 150-microm-wide, 240-microm-deep channel etched in a 3.2-cm-square silicon chip, covered with a Pyrex wafer, and coated with a dimethyl polysiloxane stationary phase is used for the GC separation of volatile organic compounds. The column, which generates approximately 5500 theoretical plates, is temperature-programmed in a conventional convection oven. The column is connected through a heated transfer line to a microfabricated differential mobility spectrometer. The spectrometer incorporates a 63Ni source for atmospheric-pressure chemical ionization of the analytes. Nitrogen or air transport gas (flow 300 cm(3)/min) drives the analyte ions through the cell. The spectrometer operates with an asymmetric radio frequency (RF) electric field between a pair of electrodes in the detector cell. During each radio frequency cycle, the ion mobility alternates between a high-field and a low-field value (differential mobility). Ions oscillate between the electrodes, and only ions with an appropriate differential mobility reach a pair of biased collectors at the downstream end of the cell. A compensation voltage applied to one of the RF electrodes is scanned to allow ions with different differential mobilities to pass through the cell without being annihilated at the RF electrodes. A unique feature of the device is that both positive and negative ions are detected from a single experiment. The combined microfabricated column and detector is evaluated for the analysis of volatile organic compounds with a variety of functionalities.
Keywords
Organic-compounds; Exposure-levels; Exposure-assessment; Air-quality; Air-quality-control; Air-quality-monitoring; Organic-vapors; Gas-chromatography; Gas-sampling; Gases; Electrochemical-analysis; Electrochemical-properties; Electrochemical-reactions; Electrochemistry; Electrophysiological-measurements; Ion-transport; Temperature-control; Atmospheric-pressure; Atmosphere-analyzers; Chemical-reactions
Contact
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109
CODEN
ANCHAM
Publication Date
20051201
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003692
Issue of Publication
23
ISSN
0003-2700
Source Name
Analytical Chemistry
State
MI
Performing Organization
University of Michigan, Ann Arbor
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