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Genetic susceptibility in pneumoconiosis.

Authors
Yucesoy-B; Luster-MI
Source
Toxicol Lett 2007 Feb; 168(3):249-254
NIOSHTIC No.
20031667
Abstract
A large number of cellular mediators such as cytokines, antioxidants and growth factors have been implicatec in the pathogenesis of chronic inflammatory and fibrotic diseases. Common functional polymorphisms in these genes have been shown to influence individual susceptibility to these diseases. Silicosis, coal worker pneumoconiosis, progressive massive fibrosis and berylliosis are examples of fibrotic pneumoconiosis and are characterized by irreversible fibrotic lesions in the lung resulting. from chronic dust inhalation. Although the materials are the major contributory factors of the disease pathogenesis, not all individuals exposed to similar levels develop disease. This suggests that there is a genetic predisposition to their development. Therefore, an understanding of genetic variability and the interaction between genetic and environmental factors is crucial to the identification of high-risk individuals and prevention and treatment of these diseases.
Keywords
Genetics; Genetic-factors; Pneumoconiosis; Silicosis; Fibrosis; Lung-disease; Occupational-diseases; Diseases; Occupational-exposure; Dusts; Dust-particles; Dust-exposure; Etiology; Pulmonary-system-disorders; Lung-function; Lung-fibrosis; Environmental-contamination; Environmental-exposure; Environmental-factors; Environmental-hazards
Contact
B Yucesoy, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
TOLED5
Publication Date
20070205
Document Type
Journal Article
Email Address
yab7@cdc.gov
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0378-4274
NIOSH Division
HELD
Source Name
Toxicology Letters
State
WV
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