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Preventing occupational exposures to antineoplastic drugs in health care settings.

Authors
Connor-TH; McDiarmid-MA
Source
CA Cancer J Clin 2006 Nov-Dec; 56(6):354-365
NIOSHTIC No.
20031368
Abstract
The toxicity of antineoplastic drugs has been well known since they were introduced in the 1940s. Because most antineoplastic drugs are nonselective in their mechanism of action, they affect noncancerous as well as cancerous cells, resulting in well-documented side effects. During the 1970s, evidence came to light indicating health care workers may be at risk of harmful effects from antineoplastic drugs as a result of occupational exposure. Since that time, reports from several countries have documented drug contamination of the work-place, identified drugs in the urine of health care workers, and measured genotoxic responses in workers. Evidence also exists of teratogenic and adverse reproductive outcomes and increased cancers in health care workers. During the past 30 years, professional organizations and government agencies have developed guidelines to protect health care workers from adverse effects from occupational exposure to antineoplastic drugs. Although many safety provisions were advanced to reduce worker exposure in the 1980s, recent studies have shown that workers continue to be exposed to these drugs despite safety policy improvements. In 2004, the National Institute for Occupational Safety and Health (NIOSH) published an alert reviewing the most recent information available and promoting a program of safe handling during their use.
Keywords
Health-care; Drugs; Health-care-personnel; Occupational-exposure; Risk-factors; Risk-analysis; Genotoxic-effects; Genotoxicity; Cancer; Toxins; Toxic-effects; Workers; Worker-health
CODEN
CAMCAM
Publication Date
20061101
Document Type
Journal Article
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0007-9235
NIOSH Division
DART
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
CA: A Cancer Journal for Clinicians
State
OH; MD
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