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Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats.

Authors
Krajnak-K; Waugh-S; Miller-R; Baker-B; Geronilla-K; Alway-SE; Cutlip-RG
Source
Muscle Nerve 2006 Dec; 34(6):720-730
NIOSHTIC No.
20031363
Abstract
Aging impairs the ability of muscle to adapt to exercise or injury. The goal of this study was to determine whether age-related changes in muscle adaptability could be the result of satellite cell apoptosis. Ten days after exposure to an injury protocol, estimates of edema in the exposed tibialis anterior muscles were higher in old (30 months) than young (3 months) rats, and isometric force levels were lower in old rats. Both young and old rats displayed an increase in MyoD labeling in the exposed muscle, indicating that injury induced satellite-cell activation. However, there were more MyoD-labeled cells that coexpressed the proapoptotic factor, Bax, in old than in young rats, suggesting that decrements in muscle recovery may be associated with an increase in satellite-cell apoptosis. Based on these findings we conclude that reducing satellite-cell apoptosis in aged animals may improve muscle recovery after injury.
Keywords
Laboratory-animals; Animals; Animal-studies; Muscles; Muscle-contraction; Injuries; Exposure-levels; Exposure-assessment; Muscle-cells
Contact
Kristine Krajnak, Engineering and Controls Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS 2027, Morgantown, West Virginia 26505, USA
CODEN
MUNEDE
Publication Date
20061201
Document Type
Journal Article
Email Address
ksk1@cdc.gov
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0148-639X
NIOSH Division
HELD
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Muscle & Nerve
State
WV
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