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Biomarkers in monitoring for efficacy of immunotherapy and chemoprevention of bladder cancer with dimethylsulfoxide.

Authors
Hemstreet-GP-3rd; Rao-J; Hurst-RE; Bonner-RB; Mellott-JE; Rooker-GM
Source
Cancer Detect Prev 1999 Mar; 23(2):163-171
NIOSHTIC No.
20031361
Abstract
This study correlated biomarkers expressed in tumor and epithelial field with clinical response and recurrence. Of 25 bladder cancer patients, 11 received 6 weeks of intravesical Bacille Calmette-Guerin (BCG), and 14 were treated weekly with intravesical dimethylsulfoxide (DMSO) for 4 weeks to further modulate biomarker expression. G-actin, DNA aneuploidy, and p300 tumor antigen were evaluated by quantitative fluorescence image analysis on uroepithelial cells from bladder wash samples prior to and immediately following treatment. Excluding patients who did not respond to BCG (and who had persistently abnormal p300 and DNA markers), recurrence correlated with persistent abnormal G-actin findings. Of patients who were G-actin negative following therapy, only 25% recurred during follow-up in contrast to 67% in patients who were positive (p < 0.03 by Fisher's exact test). The odds ratio for recurrence was 6.00 (95% confidence interval: 1.3-28.6). Cytosolic G-actin levels can be an important intermediate end point marker for chemoprevention.
Keywords
Cancer; DNA-damage; Cytotoxic-effects; Carcinogens; Carcinogenesis; Risk-analysis; Epidemiology; Biological-monitoring
Contact
Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City
CODEN
CDPRD4
Publication Date
19990301
Document Type
Journal Article
Funding Amount
1994426
Funding Type
Grant
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02647
Issue of Publication
2
ISSN
0361-090x
Source Name
Cancer Detection and Prevention
State
OK
Performing Organization
University of Oklahoma Hlth Sciences Ctr, Oklahoma City, Oklahoma
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