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Increased cancer risk among relatives of nonsmoking lung cancer cases.

Authors
Schwartz-AG; Rothrock-M; Yang-P; Swanson-GM
Source
Genet Epidemiol 1999; 17(1):1-15
NIOSHTIC No.
20031351
Abstract
Lung cancer has been shown to aggregate in families of nonsmoking lung cancer cases with an earlier age at onset. The current study evaluates whether relatives of nonsmoking lung cancer cases are at increased risk of cancers at sites other than lung. Families were identified through 257 population-based, nonsmoking lung cancer cases and 277 population-based, nonsmoking controls residing in metropolitan Detroit. Data were collected for 2,252 relatives of cases and 2,408 relatives of controls. First-degree relatives of nonsmoking lung cancer cases were at 1.52-fold (95% CI, 1.02-2.27) increased risk of cancer of the digestive system after adjustment for each relative's age, race, sex, and smoking status. Relative risk estimates also were elevated, but not significantly, for tobacco-related cancers (RR = 1.39) and breast cancer (RR = 1.72). Among first-degree relatives of younger probands (age 40-59), risk was non-significantly increased 72% (95% CI 0.95-3.10) for all cancers combined and 3.14-fold for cancers of the digestive system (95% CI 0.76-12.9). Nonsmoking relatives of cases were at increased risk of all cancer sites combined (RR = 1.32; 95% CI 1.003-1.73), cancers other than lung (RR = 1.37; 95% CI 1.03-1.82), and digestive system cancers (RR = 2.01; 95% CI 1.20-3.37). These findings of moderate familial aggregation for cancers of the lung, digestive system, breast, and tobacco-related sites suggest that common susceptibility genes may act to increase risk for a variety of cancers in families.
Keywords
Epidemiology; Risk-factors; Risk-analysis; Cancer; Lung-cancer; Demographic-characteristics; Age-factors; Age-groups; Lung-disease; Diseases; Genetics; Environmental-exposure; Case-studies
Contact
Department of Human Genetics, MCP Hahnemann School of Medicine, Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania
Publication Date
19990101
Document Type
Journal Article
Funding Amount
1233788
Funding Type
Grant
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002067
Issue of Publication
1
ISSN
0741-0395
Source Name
Genetic Epidemiology
State
PA; MI
Performing Organization
Michigan Cancer Foundation, Detroit, Michigan
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