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Organophosphate neuropathy due to methamidophos: biochemical and neurophysiological markers.

Authors
McConnell-R; Delgado-Tellez-E; Cuadra-R; Torres-E; Keifer-M; Almendarez-J; Miranda-J; El-Fawal-HA; Wolff-M; Simpson-D; Lundberg-I
Source
Arch Toxicol 1999 Aug; 73(6):296-300
NIOSHTIC No.
20031299
Abstract
Neuropathy target esterase (NTE), the putative target enzyme for organophosphate induced delayed polyneuropathy (OPIDP), can be measured in lymphocytes but has rarely been assessed in acute human poisoning. Serum autoantibodies to nervous system proteins develop in hens poisoned with neuropathic insecticides and also have not been studied after human poisoning. Serial lymphocyte NTE (LNTE) was measured in a 16-year-old boy after acute poisoning with methamidophos for evaluation as a predictor of subsequent neuropathy. The profiles of serum autoantibodies to neurofilament triplet proteins, myelin basic protein, and glial fibrillary acidic protein were measured in order to characterize changes occurring as a result of OPIDP. Clinical neuropathy characterized by steppage gate and profound lower extremity weakness, decreased grip and pinch strength, and decreased ulnar and absent tibial compound muscle action potentials developed 2 weeks following poisoning. Sensory examination and nerve conduction studies were normal. On day 3 following poisoning LNTE was depressed (77% compared with subsequent baseline enzyme activity). Marked increases in serum immunoglobulin G (IgG) autoantibodies to glial fibrillary acidic protein and to neurofilament 200 were observed after the development of OPIDP. We conclude that inhibition of lymphocyte NTE is predictive of subsequent OPIDP. Serum autoantibody titers to nervous system proteins may be useful markers of neuropathy.
Keywords
Organo-phosphorus-pesticides; Pesticides-and-agricultural-chemicals; Insecticides; Insecticide-poisoning; Pesticides; Neuropathy; Peripheral-nervous-system; Peripheral-motor-system; Protein-biochemistry
Contact
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, CA, USA
CODEN
ARTODN
CAS No.
10265-92-6; 2921-88-2
Publication Date
19990801
Document Type
Journal Article
Email Address
rmcconne@hsc.usc.edu
Funding Amount
161987
Funding Type
Grant
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000123
Issue of Publication
6
ISSN
0340-5761
Priority Area
Exposure Assessment Methods; Work Environment and Workforce
Source Name
Archives of Toxicology
State
NY; CA
Performing Organization
Division of Environmental and Occupational Medicine, Department of Community Medicine, Mount Sinai School of Medicine, New York, New York
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