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Exposure assessment in the National Children's Study: introduction.

Authors
Needham-LL; Ozkaynak-H; Whyatt-RM; Barr-DB; Wang-RY; Naeher-L; Akland-G; Bahadori-T; Bradman-A; Fortmann-R; Liu-LJ; Morandi-M; O'Rourke-MK; Thomas-K; Quackenboss-J; Ryan-PB; Zartarian-V
Source
Environ Health Perspect 2005 Aug; 113(8):1076-1082
NIOSHTIC No.
20031212
Abstract
The science of exposure assessment is relatively new and evolving rapidly with the advancement of sophisticated methods for specific measurements at the picogram per gram level or lower in a variety of environmental and biologic matrices. Without this measurement capability, environmental health studies rely on questionnaires or other indirect means as the primary method to assess individual exposures. Although we use indirect methods, they are seldom used as stand-alone tools. Analyses of environmental and biologic samples have allowed us to get more precise data on exposure pathways, from sources to concentrations, to routes, to exposure, to doses. They also often allow a better estimation of the absorbed dose and its relation to potential adverse health outcomes in individuals and in populations. Here, we make note of various environmental agents and how best to assess exposure to them in the National Children's Study--a longitudinal epidemiologic study of children's health. Criteria for the analytical method of choice are discussed with particular emphasis on the need for long-term quality control and quality assurance measures.
Keywords
Environmental-health; Exposure-assessment; Children; Questionnaires; Epidemiology; Analytical-methods; Environmental-health-monitoring; Allergens; Environmental-exposure; Organic-chemicals
Contact
L.L. Needham, Mailstop F17, 4770 Buford Highway, Atlanta, GA 30341 USA
CODEN
EVHPAZ
Publication Date
20050801
Document Type
Journal Article
Email Address
lneedham@cdc.gov
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T01-CCT-910446
Issue of Publication
8
ISSN
0091-6765
Source Name
Environmental Health Perspectives
State
AZ; GA
Performing Organization
University of Arizona, Tucson, Arizona
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