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Serum pneumoproteins: a cross-sectional comparison of firefighters and police.

Authors
Burgess-JL; Witten-ML; Nanson-CJ; Hysong-TA; Sherrill-DL; Quan-SF; Gerkin-R; Bernard-AM
Source
Am J Ind Med 2003 Sep; 44(3):246-253
NIOSHTIC No.
20031206
Abstract
Serum pneumoproteins provide a measure of the permeability of the lower respiratory tract, and have shown promise as a biomarker of acute and chronic exposure to respiratory toxicants. To evaluate the effects of chronic occupational smoke exposure, 105 firefighters were compared with 44 police controls in a cross-sectional study using spirometry, diffusing capacity of the lung, serum Clara cell protein (CC16), and serum surfactant-associated protein A (SP-A) measurements. There were no significant differences in age, gender, height, spirometry (FVC and FEV(1)), and diffusing capacity between the two groups. Serum SP-A was lower in firefighters (260.1 +/- 121.2 microg/L) than police (316.0 +/- 151.4 microg/L, P = 0.019). Serum CC16 was also lower in firefighters (8.39 +/- 3.11 microg/L) than police (10.56 +/- 4.20 microg/L, P < 0.001), although this difference lost statistical significance when adjusted for confounders. Firefighters have lower serum concentrations of SP-A than do police. Although the clinical significance of this finding is presently unknown, SP-A deserves further study as a biomarker of toxic exposure to the lower respiratory tract.
Keywords
Fire-fighters; Police-officers; Occupational-exposure; Proteins; Spirometry; Pulmonary-system; Surfactants; Respiratory-function-tests; Biomarkers; Toxins; Chronic-exposure; Smoke-control; Smoke-inhalation; Fire-hazards; Emergency-responders
Contact
Jefferey L. Burgess, Environmental and Occupational Health, University of Arizona College of Public Health, 1435 N. Fremont, Box 210468, Tucson, AZ 85719-4197, USA
CODEN
AJIMD8
Publication Date
20030901
Document Type
Journal Article
Email Address
jburgess@u.arizona.edu
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T01-CCT-910446
Issue of Publication
3
ISSN
0271-3586
Source Name
American Journal of Industrial Medicine
State
AZ
Performing Organization
University of Arizona, Tucson, Arizona
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