Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Impact of silanol surface density on the toxicity of silica aerosols measured by erythrocyte haemolysis.

Authors
Murashov-V; Harper-M; Demchuk-E
Source
J Occup Environ Hyg 2006 Dec; 3(12):718-723
NIOSHTIC No.
20031188
Abstract
Exposures to silica-containing dusts are associated with a risk of developing life-threatening lung diseases. However, the mechanism of silica toxicity is poorly understood. In this work the atomic structure of the surfaces of different silica polymorphs was determined, and a relationship with in vitro silica toxicity was examined. The density of geminal and single silanol groups was quantitatively estimated for different silica polymorphs using a novel molecular modeling method. An association was found between the reported haemolytic activity and modeled densities of surface geminal (but not single) silanol groups on several silica polymorphs. These findings suggest a new view of aerosol toxicity based on the estimation of surface site densities. The results can be used in the development of new toxicological assays for respirable particulates, including nanomaterials.
Keywords
Toxins; Toxicology; Silicates; Silica-dusts; Aerosols; Aerosol-particles; Dusts; Dust-particles; Dust-exposure; Risk-factors; Risk-analysis; Lung-disease; Diseases; Quantitative-analysis; Respirable-dust; Nanotechnology
Contact
Vladimir Murashov, National Institute for Occupational Safety and Health, Room 733G, 200 Independence Ave., Washington, D.C., 20201
CODEN
JOEHA2
Publication Date
20061201
Document Type
Journal Article
Email Address
vem8@cdc.gov
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
12
ISSN
1545-9624
NIOSH Division
HELD
Source Name
Journal of Occupational and Environmental Hygiene
State
WV
TOP