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Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite.

Authors
Powley-MW; Carlson-GP
Source
Toxicol Lett 2001 Dec; 125(1-3):117-123
NIOSHTIC No.
20031158
Abstract
Benzene is an occupational and environmental toxicant. The major health concern for humans is acute myelogenous leukemia. To exert its toxic effects, benzene must be metabolized by cytochrome P450 to phenol and subsequently to catechol and hydroquinone. Previous research has implicated CYP2E1 in the metabolism of phenol. In this study the cytochrome P450 isozymes involved in the metabolism of phenol were examined in hepatic and pulmonary microsomes utilizing chemical inhibitors of CYP2E1, CYP2B, and CYP2F2 and using CYP2E1 knockout mice. CYP2E1 was found to be responsible for only approximately 50% of 20 microM phenol metabolism in the liver. This suggests another isozyme(s) is involved in hepatic phenol metabolism. In pulmonary microsomes both CYP2E1 and CYP2F2 were significantly involved.
Keywords
Metabolism; Phenols; Metabolites; Benzenes; Toxins; Occupational-health; Occupational-hazards; Environmental-health; Environmental-hazards; Toxic-effects; Laboratory-animals; Animals; Animal-studies
Contact
School of Health Sciences, Purdue University, 1338 Civil Engineering Building, West Lafayette, IN 47907-1338, USA
CODEN
TOLED5
CAS No.
71-43-2
Publication Date
20011215
Document Type
Journal Article
Email Address
gcarlson@purdue.edu
Funding Type
Grant
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T01-OH-008615
Issue of Publication
1-3
ISSN
0378-4274
Source Name
Toxicology Letters
State
IN
Performing Organization
Purdue University, School of Health Sciences, West Lafayette, Indiana
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