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Validation of the NES2 in patients with neurologic disorders.

Authors
White-RF; Diamond-R; Krengel-M; Lindem-K; Feldman-RG; Letz-R; Eisen-E; Wegman-D
Source
Neurotoxicol Teratol 1996 Jul-Aug; 18(4):441-448
NIOSHTIC No.
20031096
Abstract
Performance on the Neurobehavioral Evaluation System (NES) has been demonstrated to be affected by exposure to a variety of neurotoxicants. However, the relation of NES subtests to CNS function has not yet been documented in patients diagnosed with neurologic disorders known to implicate specific brain substrates. A validation study of the NES2 was carried out in patients with multiple sclerosis (MS) and Parkinson's disease (PD), disorders exhibiting neuropathology at loci (white matter in MS, basal ganglia in PD) believed to be the sites of action of several known neurotoxicants. The results indicated that performance on certain NES2 subtests was affected in expected ways in both types of patients. However, performance on many more subtests was impaired, relative to controls, in MS than in PD. The relative insensitivity to PD suggests that expansion and refinement of the battery are required if it is to serve well in detecting the effects of toxicants in subjects without frank physical symptoms. These are the goals of a new version of the instrument currently under development (NES3).
Keywords
Neurotoxicology; Neurotoxicity; Neurotoxins; Neurotoxic-effects; Neurological-system; Neurological-reactions; Neurological-diseases; Exposure-assessment; Diseases; Nervous-system-disorders
Contact
Roberta F. White, Boston Department of Veterans Administration Medical Center, Boston Environmental Hazards Center and the Neurology and Psychology Services, 150 South Huntington Avenue 116B-4, Boston, MA 02130
CODEN
NETEEC
Publication Date
19960701
Document Type
Journal Article
Funding Amount
560772
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002767
Issue of Publication
4
ISSN
0892-0362
Priority Area
Neurotoxic Disorders
Source Name
Neurotoxicology and Teratology
State
MA
Performing Organization
Boston University, Boston, Massachusetts
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