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Familial risk of lung cancer among nonsmokers and their relatives.

Authors
Schwartz-AG; Yang-P; Swanson-GM
Source
Am J Epidemiol 1996 Sep; 144(6):554-562
NIOSHTIC No.
20031094
Abstract
The role of family history of lung cancer in predicting lung cancer risk among nonsmokers and their relatives was evaluated in a population-based family study conducted in metropolitan Detroit. Lung cancer risk factor data were collected through telephone interviews with 257 nonsmoking lung cancer cases 40-84 years of age diagnosed between 1984 and 1987, their 2,252 relatives, 277 nonsmoking controls, and their 2,408 relatives. Lung cancer in a first-degree relative was associated with a 7.2-fold (95% confidence interval 1.3-39.7) increased risk of lung cancer among nonsmokers in the 40- to 59-year-old age group. This significant increased risk remained after adjustment for the smoking, occupational, and medical history of each family member (relative risk = 6.1, 95% confidence interval 1.1-33.4). Offspring of nonsmoking cases comprised another lung cancer high risk group (relative risk = 7.2, 95% confidence interval 0.5-103). A positive family history did not increase lung cancer risk among nonsmokers 60-84 years of age or their relatives. These findings suggest that susceptibility to lung cancer in families of nonsmoking cases may be evident only in a subset of relatives of early-onset nonsmoking cases.
Keywords
Epidemiology; Risk-factors; Risk-analysis; Cancer; Lung-cancer; Demographic-characteristics; Age-factors; Age-groups; Lung-disease; Diseases; Genetics; Environmental-exposure; Models; Case-studies
CODEN
AJEPAS
Publication Date
19960915
Document Type
Journal Article
Funding Amount
1233788
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002067
Issue of Publication
6
ISSN
0002-9262
Source Name
American Journal of Epidemiology
State
PA; MI
Performing Organization
Michigan Cancer Foundation, Detroit, Michigan
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