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Evoked-potential thresholds and cubic distortion product otoacoustic emissions in the chinchilla following carboplatin treatment and noise exposure.

Authors
Jock-BM; Hamernik-RP; Aldrich-LG; Ahroon-WA; Petriello-KL; Johnson-AR
Source
Hear Res 1996 Jul; 96(1-2):179-190
NIOSHTIC No.
20031090
Abstract
Twenty-two chinchillas were given either a single intraperitoneal (i.p.) or intravenous (i.v.) injection (50 or 75 mg/kg) of Paraplatin, an asymptotic threshold shift-producing noise or a combination of the drug and noise in series. Auditory evoked potential (pure-tone) audiograms and cubic distortion product otoacoustic emissions were obtained on each animal before and after treatment, and the sensory epithelium of the cochlea was evaluated using the surface preparation method. Anatomical analysis indicated that the carboplatin alone caused relatively severe but scattered losses of inner hair cells throughout most of the cochlea which were dependent on dose and administration route. The outer sensory cell population remained essentially intact. In animals that had up to 40% scattered losses of only inner hair cells, evoked potential thresholds were near normal and the emission functions either were normal or showed an enhanced output. The severe losses of inner hair cells produced by the drug had no effect on the threshold shift dynamics produced by a five-day uninterrupted noise exposure. In general, there was not a consistent relation between the emission data and both the permanent threshold shift and outer hair cell losses.
Keywords
Noise; Noise-exposure; Noise-induced-hearing-loss; Hearing-loss; Animal-studies; Animals; Models; Diseases; Acoustics; Auditory-system; Author Keywords: Hearing loss; Otoacoustic emission; Carboplatin
Contact
Auditory Research Laboratory, 107 Beaumont Hall, State University of New York, Plattsburgh, NY 12901, USA
CODEN
HERED3
CAS No.
41575-94-4
Publication Date
19960701
Document Type
Journal Article
Email Address
ahroonwa@splava.cc.plattsburgh.edu
Funding Amount
2829511
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002317
Issue of Publication
1-2
ISSN
0378-5955
Source Name
Hearing Research
State
NY
Performing Organization
State University of New York at Buffalo, Buffalo, New York
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