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The Upper Midwest Health Study: a case-control study of primary intracranial gliomas in farm and rural residents.

Authors
Ruder-AM; Waters-MA; Carreón-T; Butler-MA; Davis-King-KE; Calvert-GM; Schulte-PA; Ward-EM; Connally-LB; Lu-J; Wall-D; Zivkovich-Z; Heineman-EF; Mandel-JS; Morton-RF; Reding-DJ; Rosenman-KD; Brain Cancer Collaborative Study Group
Source
J Agric Saf Health 2006 Nov; 12(4):255-274
NIOSHTIC No.
20031076
Abstract
Since several studies indicated that farmers and agricultural workers had an excess risk of brain cancer, the National Institute for Occupational Safety and Health initiated the Upper Midwest Health Study to examine risk of intracranial glioma in the non-metropolitan population. This population-based, case-control study evaluated associations between gliomas and rural and farm exposures among adults (ages 18 to 80) in four upper Midwestern states (Iowa, Michigan, Minnesota, Wisconsin). At diagnosis/selection, participants lived in non-metropolitan counties where the largest population center had fewer than 250,000 residents. Cases were diagnosed 1 January 1995 through 31 January 1997. Over 90% of 873 eligible ascertained cases and over 70% of 1670 eligible controls consented to participate. Participants and nonparticipants, evaluated for "critical questions" on main and refusant questionnaires, differed significantly in farming and occupational experience, ethnicity, education, and lifestyle. The 1175 controls were more likely than the 798 cases to have reported ever drinking alcohol (77% vs. 73%, adjusted odds ratio (OR) 0.73, 95% confidence interval (CI) 0.59-0.92) and having had panoramic dental x-rays (34% vs. 29%, OR 0.75, CI 0.61-0.92). Controls spent a greater percentage of their lives in non-metropolitan counties (78% vs. 75%, OR 0.81, CI 0.67-1.09). Among ever-farmers, controls were more likely to have had exposure to farm insecticides (57% vs. 50%, OR 0.75, CI 0.59-0.95) and farm animals (96% vs. 91%, OR 0.48, CI 0.25-0.90). Moving to a farm as an adolescent (ages 11 to 20) vs. as an adult was associated with a greater risk of glioma (OR 1.96, CI 1.13-3.39). In our study sample, farm or rural residence and summary farm exposures were associated with decreased glioma risk. However, nonparticipation by never-farming eligible controls could have affected results. Comparisons of farm chemical exposures may clarify associations between farming and glioma that others have reported.
Keywords
Epidemiology; Demographic-characteristics; Agricultural-workers; Agricultural-chemicals; Farmers; Age-factors; Sex-factors; Racial-factors; Pesticides-and-agricultural-chemicals; Pesticides; Author Keywords: Agricultural workers; Agriculture; Agrochemicals; Case-control study; Glioma; Proxy; Study design
Contact
Avima M. Ruder, National Institute for Occupational Safety and Health, Mailstop R-16, 4676 Columbia Parkway, Cincinnati, OH 45226
CODEN
JASHFD
Publication Date
20061101
Document Type
Journal Article
Email Address
amr2@cdc.gov
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
1074-7583
NIOSH Division
DSHEFS; EID; DART
Source Name
Journal of Agricultural Safety and Health
State
OH; GA; IA; MI; MN; WI
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