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Transcellular route of diffusion through stratum corneum: results from finite element models.

Authors
Barbero-AM; Frasch-HF
Source
J Pharm Sci 2006 Oct; 95(10):2186-2194
NIOSHTIC No.
20031040
Abstract
Insight into the stratum corneum (SC) permeation pathway for hydrophilic compounds is gained by comparing experimental measurements of permeability and lag time (tlag) with the predictions of a finite element (FE) model. A database of permeability and lag time measurements (n=27) of hydrophilic compounds was compiled from the literature. Transcellular and lateral lipid diffusion pathways were modeled within a brick-and-mortar geometry representing fully hydrated human SC. Modeled tlag's for the lipid pathway are too brief to account for the experimental quantities, whereas the transcellular pathway with preferential corneocyte partitioning does account for them. Measured tlag's are highly correlated (p<0.0001) with the compound's octanol-water partition coefficient, supporting the hypothesis of an aqueous-lipid partition mechanism in the permeation of hydrophilic compounds. The importance of the lag time for identifying the diffusion pathway is demonstrated.
Keywords
Models; Skin-absorption; Diffusion-analysis; Mathematical-models; Pharmaceuticals
Contact
H. Frederick Frasch, Health Effects Laboratory, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505
CODEN
JPMSAE
Publication Date
20061001
Document Type
Journal Article
Email Address
HFrasch@cdc.gov
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
10
ISSN
0022-3549
NIOSH Division
HELD
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
Journal of Pharmaceutical Sciences
State
WV
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