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Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder.

Authors
Inslicht-SS; Marmar-CR; Neylan-TC; Metzler-TJ; Hart-SL; Otte-C; McCaslin-SE; Larkin-GL; Hyman-KB; Baum-A
Source
Psychoneuroendocrinology 2006 Aug; 31(7):825-838
NIOSHTIC No.
20031007
Abstract
Alterations of hypothalamic-pituitary-adrenal (HPA) axis function and sympathetic-adrenal activity have been proposed as key factors in biological models of posttraumatic stress disorder (PTSD). We examined neuroendocrine function in female survivors of intimate partner violence (IPV) with lifetime (current or remitted) PTSD (n=29) and in women who were exposed to IPV but never developed PTSD (n=20). Salivary cortisol was collected as a marker of HPA axis function at 1, 4, 9, and 11 h after awakening. Platelet epinephrine and norepinephrine were assayed as markers of sympathetic-adrenal activation. Women with lifetime PTSD had significantly higher cortisol levels across the day compared to abuse-exposed participants without PTSD, after controlling for age, depression, severity, and latency of abuse. There were no significant group differences in levels of platelet catecholamines. Elevated cortisol levels may be a biomarker of IPV-related lifetime PTSD, reflecting long-lasting changes associated with trauma-exposure or possibly a reflection of risk for PTSD in women.
Keywords
Traumatic-injuries; Stress; Pregnancy; Women; Injuries; Health-hazards; Metabolism; Etiology
Contact
Department of Psychology, University of Pittsburgh Sennott Square, 3rd Floor, 210 S. Bouquet Street, Pittsburgh, PA 15260, USA
CODEN
PSYCDE
Publication Date
20060801
Document Type
Journal Article
Email Address
sabra.inslicht@ucsf.edu
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003306
Issue of Publication
7
ISSN
0306-4530
Source Name
Psychoneuroendocrinology
State
PA; CA; TX
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