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Strawberries inhibit cancer cell proliferation.

Authors
Wang-SO; Lewers-K; Bowman-L; Ding-M
Source
HortScience 2006 Jul; 41(4):1082
NIOSHTIC No.
20030997
Abstract
Representatives of three species of strawberries (Fragaria virginiana, F chiloensis and F x ananassa) were evaluated for antioxidant capacity, scavenging capacity for reactive oxygen species (ROO, -OH , (1)0(2) and O(2)), and inhibitory effect on proliferation of A549 human lung epithelial cancer cells. Differences among the strawberry genotypes were observed for all three qualities. High antioxidant and scavenging capacities were found in 'CFRA 0982', 'JP 95-1-1', NC 95-19-1 and RH 30. Lowest antioxidant and scavenging capacities were found in 'AlIstar'. There was also a relationship between scavenging capacity and the inhibition of cancer cell proliferation. The correlations (R2) between the scavenging capacities for the reactive oxygen species and the inhibition of cancer cell proliferation were 0.8074, 0.8279, 0.7862 and 0.7761 for ROO, -OH, (1)0(2) and O(2), respectively. These results suggest that antioxidants, specifically their scavenging capacities, may play an important role in the antiproliferative activity of strawberries. This study also identified strawberry germplasm of value in developing cultivars useful for cancer prevention.
Keywords
Cancer; Antioxidants; Free-radicals; Antineoplastic-agents; Disease-prevention
CODEN
HJHSAR
Publication Date
20060701
Document Type
Abstract; Conference/Symposia Proceedings
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0018-5345
NIOSH Division
HELD
Priority Area
Research Tools and Approaches: Cancer Research Methods
Source Name
HortScience
State
WV; MD
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