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Considerations in estimating social and economic impacts of immunotoxic agents.

Authors
Blanciforti-LA; Luster-MI
Source
Hum Ecol Risk Assess 2006 Oct; 12(5):888-903
NIOSHTIC No.
20030951
Abstract
To make appropriate regulatory policy decisions, the potential social and economic impacts of the policy must first be established. For environmental and occupational agents, social and economic impacts are derived from animal toxicology and, when available, human studies that serve as the base for risk-benefit analysis (RBA). Because immune function is associated with resistance to infectious disease, developing RBA for data derived from immunotoxicology studies will require determining the changes in the frequency or severity of infectious disease resulting from an exposure. Fortunately, considerable information is readily available for identifying the frequency of infectious diseases in the general population and its social and economic impacts and to assist the risk assessor when conducting RBA for immunotoxicology endpoints. The following is a brief review describing some issues in using immunotoxicity data when conducting RBA. It presents an economic methodology to determine the economic impacts of infectious diseases to society, sources where these types of information are available, and an example using a specific infectious disease, otitis media.
Keywords
Immunotoxins; Risk-factors; Risk-analysis; Toxins; Toxicology; Toxic-effects; Occupational-exposure; Infectious-diseases; Immune-reaction; Immune-system-disorders
CODEN
HERAFR
Publication Date
20061001
Document Type
Journal Article
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
1080-7039
NIOSH Division
HELD
Source Name
Human and Ecological Risk Assessment
State
WV
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