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Comparison of continuous and intermittent vibration effects on rat-tail artery and nerve.

Authors
Govindaraju-SR; Curry-BD; Bain-JL; Riley-DA
Source
Muscle Nerve 2006 Aug; 34(2):197-204
NIOSHTIC No.
20030888
Abstract
Hand-transmitted vibration from powered-tools can cause peripheral vasospasm and neuropathy. A rat-tail model was used to investigate whether the pattern of vibration influenced the type and severity of tissue damage. The tails of awake rats were vibrated continuously or intermittently for a total of 4 hours at 60 HZ, 49 m/s(2). Nerves and arteries were harvested immediately or 24 hours after treatment. Tails subjected to intermittent vibration showed transiently increased sensitivity to thermal stimuli. Intermittent vibration caused the most nerve injury immediately and 24 hours after vibration. Continuous vibration invoked a persistent reduction in vascular lumen size. Compared to epinephrine-induced transient vacuolation in vascular smooth muscle cells, both continuous and intermittent vibration caused greater persistence of vacuoles, indicating a vibration-induced pathological process. All vibration groups exhibited elevated nitrotyrosine immunoreactivity indicative of free-radical damage. Pattern of vibration exposure may exert a major influence on the type of vibration injury.
Keywords
Vibration; Vibration-effects; Laboratory-animals; Animals; Animal-studies; Nerves; Hand-tools; Hand-injuries; Neuropathy; Vibration-exposure; Exposure-levels; Exposure-assessment; Injuries; Free-radicals; Muscles; Muscle-tissue
Contact
Danny A. Riley, Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
CODEN
MUNEDE
Publication Date
20060801
Document Type
Journal Article
Email Address
dariley@mcw.edu
Funding Amount
922402
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003493
Issue of Publication
2
ISSN
0148-639X
Source Name
Muscle and Nerve
State
WI
Performing Organization
Medical College of Wisconsin, Milwaukee, Wisconsin
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