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Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation.

Authors
Antonini-JM; O'Callaghan-JP; Miller-DB
Source
Neurotoxicology 2006 Sep; 27(5):745-751
NIOSHTIC No.
20030881
Abstract
Serious questions have been raised regarding a possible causal association between neurological effects in welders and the presence of manganese in welding fume. An experimental model is needed that could examine the potential neurotoxic effect of manganese after pulmonary exposure to welding fume. The National Institute for Occupational Safety and Health (NIOSH) has recently finished construction of a completely automated, computer controlled welding fume generation and inhalation exposure system for laboratory animals. The system is comprised of a programmable six-axis robotic welding arm and a water-cooled arc welding torch. A flexible trunk has been attached to the robotic arm of the welder and is used to collect and transport fume from the vicinity of the arc to the animal exposure chamber. Preliminary fume characterization studies have indicated that particle morphology, size, and chemical composition were comparable to welding fume generated in the workplace. Animal inhalation studies are currently underway. With the development of this novel system, an animal model has been established using controlled welding exposures to investigate the possible mechanisms by which welding fume may affect the central nervous system.
Keywords
Animals; Animal-studies; Models; Neurotoxicology; Neurotoxins; Neurotoxicity; Neurotoxic-effects; Welding; Fumes; Fumigants; Inhalation-studies; Manganese-compounds; Pulmonary-system-disorders; Laboratory-animals; Exposure-chambers; Exposure-levels; Central-nervous-system
Contact
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA
CODEN
NRTXDN
Publication Date
20060901
Document Type
Journal Article
Email Address
jga6@cdc.gov
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0161-813X
NIOSH Division
HELD
Source Name
Neurotoxicology
State
WV
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