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Hard metal disease: effects of cationic metals on neurogenic responses of guinea-pig isolated airways.

Authors
Fedan-JS; Cutler-D; Renngasamy-A
Source
FASEB J 1999 Mar; 13(4)(Part 1):A170
NIOSHTIC No.
20030639
Abstract
Inhalation of the dust of industrial hard metal (IHM), which consists of tungsten carbide, Co and other metals, causes asthma and interstitial fibrosis in workers. Dissolution of the metals may occur in. the lungs. Intratracheal instillation of guinea pigs with IHM causes up-regulation of NO pathways and hyporeactivity to inhaled methacholine (MCh). To determine if neural regulation of airway diameter is also affected by IHM, we examined the effects of C02+, Cd2+ and Ni2+ on electrical field stimulation-induced neurogenic contractile and relaxant responses of guinea-pig tracheal strips. The effects of the metals (10^-6 M; 30 min) were examined in strips at resting force or contracted with MCh (3 x 10^-1 M), either in the absence or presence of indomethacin (In. 10^-6 M). No metal had any effect on the eNANC contraction phase or relaxation responses under any condition, or affected contractions or relaxations obtained in the absence of In. CO2+ inhibited contractions in MChcontracted strips (+In). Cd2+ and Ni2+ potentiated slightly contractions obtained in MCh-contracted strips (+In), but inhibited contractions obtained in the absence of MCh (+In). We conclude that following dissolution in the airway wall, metals contained in IHM may alter cholinergic neurogenic pathways.
Keywords
Laboratory-animals; Animals; Animal-studies; Inhalation-studies; Exposure-levels; Exposure-assessment; Dose-response; Metal-dusts; Metal-poisoning; Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Lung-fibrosis; Hard-metals; Hard-metal-disease
CODEN
FAJOEC
Publication Date
19990312
Document Type
Abstract; Conference/Symposia Proceedings
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0892-6638
NIOSH Division
HELD
Source Name
The FASEB Journal
State
WV; DC
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