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Metabolic functions of alveolar type II cells in acute silicosis.

Authors
Levy-RD; Hubbs-AF; Ducatman-BS; Singh-G; Vallyathan-V; Bowman-L; Miles-PR
Source
Toxicologist 1997 Mar; 36(1)(Part 2):74
NIOSHTIC No.
20030581
Abstract
We have examined some metabolic functions of alveolar type II cells during experimental silicosis in rats. Consistent with previous studies, hypertrophied and hyperplastic alveolar type II cells and alveolar lipoproteinosis were observed at two and four weeks after intratracheal administration of 20 mg silica. Both hypertrophied and normal alveolar type II cells from all exposure groups contained immunohistochemically detectable lysozyme and surfactant apoprotein. Cytochrome P450 28 I was immunohistochemically demonstrated in the Clara and normal type II cells of control and silica exposed rat lungs. However, the hypertrophied and hyperplastic alveolar type II cells contained no immunohistochemically detectable cytochrome P450 281. The concentration of P450 281 containing alveolar cells (positive cells/mm2) was unaltered by silica. These findings support the hypothesis that during experimental silicosis, the hypertrophied type II cells are a newly-induced population of alveolar cells metabolically distinct from the pre-existing type II cells.
Keywords
Toxic-dose; Toxic-materials; Toxins; Exposure-assessment; Exposure-levels; Exposure-limits; Alveolar-cells; Lung-tissue; Lung-disorders; Lung-cells; Respiratory-system-disorders; Pulmonary-system-disorders; Silicates; Silica-dusts; Silicosis
CAS No.
7631-86-9
Publication Date
19970301
Document Type
Abstract
Fiscal Year
1997
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1096-6080
NIOSH Division
HELD
Source Name
The Toxicologist. Society of Toxicology 36th Annual Meeting, March 9-13, 2006, Cincinnati, Ohio
State
OH; PA; WV
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