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In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children.

Authors
Eskenazi-B; Marks-AR; Bradman-A; Fenster-L; Johnson-C; Barr-DB; Jewell-NP
Source
Pediatrics 2006 Jul; 118(1):233-241
NIOSHTIC No.
20030518
Abstract
We investigated the relationship between prenatal exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment of Mexican farm-workers' children in California. Participants from the Center for the Health Assessment of Mothers and Children of Salinas study, a birth cohort study, included 360 singletons with maternal serum measures of p,p'-DDT, o,p'-DDT, and p,p'-DDE. Psychomotor development and mental development were assessed with the Bayley Scales of Infant Development at 6, 12, and 24 months. We found a approximately 2-point decrease in Psychomotor Developmental Index scores with each 10-fold increase in p,p'-DDT levels at 6 and 12 months (but not 24 months) and p,p'-DDE levels at 6 months only. We found no association with mental development at 6 months but a 2- to 3-point decrease in Mental Developmental Index scores for p,p'-DDT and o,p'-DDT at 12 and 24 months, corresponding to 7- to 10-point decreases across the exposure range. Even when mothers had substantial exposure, breastfeeding was usually associated positively with Bayley scale scores. Prenatal exposure to DDT, and to a lesser extent DDE, was associated with neurodevelopmental delays during early childhood, although breastfeeding was found to be beneficial even among women with high levels of exposure. Countries considering the use of DDT should weigh its benefit in eradicating malaria against the negative associations found in this first report on DDT and human neurodevelopment.
Keywords
In-utero-exposure; Children; Demographic-characteristics; Racial-factors; Prenatal-exposure; Agriculture; Agricultural-industry; Agricultural-workers; Farmers
Contact
Center for Children's Environmental Health Research, School of Public Health, University of California, Berkeley, 2150 Shattuck Ave, Suite 600, Berkeley, CA 94720-7380, USA
CODEN
PEDIAU
CAS No.
50-29-3
Publication Date
20060701
Document Type
Journal Article
Email Address
eskenazi@berkeley.edu
Funding Amount
909365
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007400
Issue of Publication
1
ISSN
0031-4005
Source Name
Pediatrics
State
CA; GA
Performing Organization
University of California, Berkeley
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