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Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity.

Authors
Ding-M; Feng-RT; Wang-SY; Bowman-L; Lu-YJ; Qian-Y; Castranova-V; Jiang-BH; Shi-XL
Source
J Biol Chem 2006 Jun; 281(25):17359-17368
NIOSHTIC No.
20030494
Abstract
Epidemiological data suggest that consumption of fruits and vegetables has been associated with a lower incidence of cancer. Cyanidin-3-glucoside (C3G), a compound found in blackberry and other food products, was shown to possess chemopreventive and chemotherapeutic activity in the present study. In cultured JB6 cells, C3G was able to scavenge ultraviolet B-induced *OH and O2-* radicals. In vivo studies indicated that C3G treatment decreased the number of non-malignant and malignant skin tumors per mouse induced by 12-O-tetradecanolyphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene-initiated mouse skin. Pretreatment of JB6 cells with C3G inhibited UVB- and TPA-induced transactivation of NF-kappaB and AP-1 and expression of cyclooxygenase-2 and tumor necrosis factor-alpha. These inhibitory effects appear to be mediated through the inhibition of MAPK activity. C3G also blocked TPA-induced neoplastic transformation in JB6 cells. In addition, C3G inhibited proliferation of a human lung carcinoma cell line, A549. Animal studies showed that C3G reduced the size of A549 tumor xenograft growth and significantly inhibited metastasis in nude mice. Mechanistic studies indicated that C3G inhibited migration and invasion of A549 tumor cells. These finding demonstrate for the first time that a purified compound of anthocyanin inhibits tumor promoter-induced carcinogenesis and tumor metastasis in vivo.
Keywords
Epidemiology; Cancer; Food; Foodstuff; Cell-cultures; In-vivo-studies; Skin-tumors; Laboratory-animals; Animals; Animal-studies; Tumors; Carcinogens; Carcinogenicity; Carcinogenesis
Contact
Pathology and Physiology Research Branch, Health Effect Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
JBCHA3
Publication Date
20060623
Document Type
Journal Article
Email Address
mid5@cdc.gov
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Issue of Publication
25
ISSN
0021-9258
NIOSH Division
HELD
Priority Area
Research Tools and Approaches: Cancer Research Methods
Source Name
Journal of Biological Chemistry
State
WV
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