Reactive airways dysfunction syndrome and irritant-induced asthma.
Gautrin-D; Bernstein-IL; Brooks-SM; Henneberger-PK
Asthma in the Workplace and Related Conditions, Third Edition. Bernstein IL, Chan-Yeun M, Malo JL, Bernstein DI, eds., New York: Taylor and Francis Group, 2006 Jan; :581-629
Although irritant-induced nonimmunological asthma without a latency period had previously been reported, the acronym for this form of occupational asthma (OA) was first derived from the descriptive term "reactive airways dysfunction syndrome" (RADS) in 1985 (1). It was originally defined as asthma occurring after a single exposure to high levels of an irritating vapor, fume, or smoke. Although the term "irritant-induced asthma (IIA) disease" is more consistent with the definitions of OA described in chapter 1, the RADS terminology was retained by the editors because of the high recognition index that it has engendered among the occupational health community as well as the specific diagnostic criteria, which distinguish it from other forms of IIA. Initial symptoms developed within minutes or hours after exposure. In the majority of cases there was continuation of obstructive symptoms and persistent airway hyperresponsiveness for more than one year. The condition is defined here as nonimmunological OA, and, according to this definition, it should be distinguished from other nonimmunological OA entities occurring after longer latent periods of exposure (e.g., meat wrappers' asthma and pot room asthma) and/or fixed obstructive disorders, such as bronchiolitis or bronchiolitis obliterans, resulting from chemical inhalation injury (Chapter 28). As more investigators recognize RADS as a unique form of OA, in future it will be most likely referred as a special phenotype of IIA (2).
Respiratory-irritants; Respiratory-system-disorders; Bronchial-asthma; Vapors; Fumes; Fumigants; Smoke-inhalation; Occupational-exposure; Occupational-health; Occupational-diseases; Diseases; Airway-resistance; Airway-obstruction; Exposure-assessment
Book or book chapter
Bernstein-IL; Chan-Yeung-M; Malo-JL; Bernstein-DI
Asthma in the Workplace and Related Conditions, Third Edition