Immunological and inflammatory assessments.
Lemiere-C; Biagini-RE; Zeiss-CR
Asthma in the Workplace and Related Conditions, Third Edition. Bernstein IL, Chan-Yeun M, Malo JL, Bernstein DI, eds., New York: Taylor and Francis Group, 2006 Jan; :179-197
The next sections discuss the different tests that can be performed to make a diagnosis in this patient. This chapter addresses the current methods for performing an immunological assessment by skin testing and by serological assays, and also describes the role of noninvasive assessment of airway inflammation by sputum cell counts. Immunologic assessment of individuals with suspected occupational asthma (OA) by skin testing has been an important tool in the diagnosis of OA, as exemplified by the classic work of Dr. J. Pepys on industrial enzymes in the detergent industry and platinum salts in the refining industry (1,2). A number of recent excellent reviews on OA and on the epidemiology of asthma in the workplace describe the extensive number and diversity of important occupational allergens (3-9). The examples of occupational agents that have been assessed by skin testing and other diagnostic studies are listed in Table I (10-64). Demonstration of skin test reactivity indicates that the worker has become sensitized to low- or high-molecular-weight allergen in the work environment and is not by itself diagnostic of OA as discussed elsewhere in this volume. The immediate wheal and flare reaction induced by prick or intradermal skin tests to occupational allergens is associated with an underlying IgE antibody-mediated response, which can also be confirmed by specific IgE in vitro assays as discussed below.
Immunology; Skin-tests; Airway-resistance; Airway-obstruction; Occupational-health; Occupational-hazards; Occupational-exposure; Occupational-diseases; Bronchial-asthma; Allergens; Workers; Worker-health; Work-environment; Immunological-tests
Book or book chapter
Bernstein-IL; Chan-Yeung-M; Malo-JL; Bernstein-DI
Asthma in the Workplace and Related Conditions, Third Edition