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The genetic and environmental factors involved in benzidine metabolism and bladder carcinogenesis in exposed workers.

Authors
Carreón-T; LeMasters-GK; Ruder-AM; Schulte-PA
Source
Front Biosci 2006 Sep; 11(1):2889-2902
NIOSHTIC No.
20030269
Abstract
Genetic susceptibility to bladder cancer in individuals exposed to arylamines may be explained by interindividual metabolic differences that lead to arylamine bioactivation or detoxification. In this article, occupational bladder cancer risk factors and the evidence that links benzidine exposure to bladder cancer are reviewed. Benzidine metabolism is described and compared with that of other aromatic amines. Metabolic polymorphisms and bladder cancer in the context of occupational exposure to aromatic amines are also reviewed, and the environmental and genetic relationships of benzidine exposure and genetic susceptibility are outlined. Only a few studies of bladder cancer genetic susceptibility in populations exposed occupationally to arylamines have been published. The results of these case-control studies show conflicting results, reflecting metabolic differences between monoarylamines and diarylamines such as benzidine. Additional studies and pooled analyses of existing data are needed to establish if individuals are at higher risk of bladder cancer given the presence of certain alleles that make them more susceptible to this disease.
Keywords
Genetic-factors; Environmental-factors; Metabolism; Carcinogens; Carcinogenicity; Carcinogenesis; Bladder-disorders; Occupational-exposure; Workers; Worker-health; Bladder-cancer; Cancer; Risk-analysis; Risk-factors; Case-studies; Diseases; Bladder-disease; Arylamines
CAS No.
92-87-5
Publication Date
20060901
Document Type
Journal Article
Email Address
tjc5@cdc.gov
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1093-9946
NIOSH Division
EID; DSHEFS
Source Name
Frontiers in Bioscience
State
OH
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