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Transitional studies.

Authors
Schulte-PA; Perera-FP
Source
Application of Biomarkers in Cancer Epidemiology. IARC Scientific Publications No. 142. P. Toniolo, P. Boffetta, D. E. G. Shuker, N. Rothman, B. Hulka and N. Pearce, eds., Lyon, France: International Agency for Research on Cancer (IARC), 1997 Dec; :19-29
Link
NIOSHTIC No.
20030150
Abstract
Transitional studies are studies using biological markers that bridge the gap between laboratory experiments and population-based epidemiology. The goal of these studies is to characterize and validate biomarkers and to assess the following: intra- and inter-subject variability; the feasibility of marker use in field conditions; confounding and effect-modifying factors for the marker; and mechanisms reflected by the biomarker. Another goal is to optimize the conditions for the use of biomarkers. Transitional studies involving biomarkers of exposure or effect are distinguished from etiological studies because the biomarker is generally the outcome or dependent variable. Despite this difference, transitional studies can-be epidemiological studies, but they may also include laboratory studies to assess reliability (and accuracy) and to identify parameters for collecting, processing and storing biological specimens prior to assay. Generally, transitional studies involve healthy people, patients or workers with specific exposures. At some point in the validation of a biomarker the line between transitional and etiological studies becomes blurred. None the less, it is useful to identify transitional studies as a distinct set of efforts to validate and characterize biomarkers. Transitional studies can be divided into three functional categories: developmental, characterization and applied studies.
Keywords
Epidemiology; Biomarkers; Humans; Sociology
Contact
Paul A. Schulte, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, C-14, Cincinnati, OH 45226
Publication Date
19971215
Document Type
Book or book chapter
Editors
Toniolo-P; Boffetta-P; Shuker-DEG; Rothman-N; Hulka-B; Pearce-N
Fiscal Year
1998
NTIS Accession No.
NTIS Price
ISBN No.
928322127
NIOSH Division
EID
Source Name
Application of Biomarkers in Cancer Epidemiology. IARC Scientific Publications No. 142
State
OH
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