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Cross-sectional study of auto body workers exposed to isocyanates: immunologic responses.

Authors
Stowe-MH; Wisnewski-AV; Holm-CT; Sparer-J; Liu-Y; Woskie-SR; Cullen-MR; Redlich-CA
Source
Proc Am Thorac Soc 2005 May; 2(Abstracts):A816
NIOSHTIC No.
20030108
Abstract
Isocyanates are a common cause of immune-mediated occupational asthma. However, the health and immunologic effects of isocyanates under current working conditions and risk factors remain poorly defined. A cross-sectional epidemiologic study of 262 body shop workers from 36 shops, Survey of Painters and Repairers of Autobodies by Yale (SPRAY), was performed to characterize isocyanate exposures and their effects on body shop workers, using questionnaires, physiologic and immunologic assessment of the workers. Individual isocyanate exposures were estimated based upon total reactive isocyanate concentration determined from air and personal sampling and personal worker activity diaries. A low prevalence of asthma (2.3%) using spirometry, methacholine challenge, symptoms, and peak flows was noted, but isocyanate-specific immunologic responses were present in 26% workers. Hexamethylene diisocyanate (HDI)-specific IgG was present in 21% of HDI-exposed workers. The presence of HDI-specific IgG was strongly associated with current total isocyanate exposure (total NCO 24.1 vs 8.8 ug NCO/m3; p = .0004), but did not correlate with race, total IgE, asthma symptoms or smoking. However, work-related asthma-like symptoms and methacholine responsiveness were more prevalent in those with higher HDI-specific IgG (>1:160). HDI specific IgE was present in 6 workers (3%), 5 of whom also had HDI-specific IgG, only one of whom had work-related asthma symptoms. These findings demonstrate that HDI-IgG is present in a substantial proportion of HDI exposed workers and correlates with current isocyanate exposure. High HDI-IgG titres may suggest isocyanate asthma.
Keywords
Automotive-industry; Occupational-exposure; Workers; Isocyanates; Immunology; Occupational-diseases; Diseases; Bronchial-asthma; Epidemiology; Air-sampling; Exposure-levels; Exposure-assessment
CODEN
PATSBB
Publication Date
20050520
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
meredith.stowe@yale.edu
Funding Amount
2634676
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003457
Issue of Publication
Abstracts
ISSN
1546-3222
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
Proceedings of the American Thoracic Society. 2005 ATS International Conference, May 20-25, 2005, San Diego, California
State
CT; MA
Performing Organization
Yale University, New Haven, Connecticut
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