Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Indicators of oxidative stress in the serum of asymptomatic shipyard welders.

Authors
Vallyathan-V; Han-SG
Source
Proc Am Thorac Soc 2005 May; 2(Abstracts):A815
NIOSHTIC No.
20030106
Abstract
Oxidative stress is believed to play a key role in the development of welding-induced diseases. The objectives of this study were to investigate the effects welding fumes on correlates of oxidative stress in serum of asymptomatic shipyard welders in South Korea. Blood samples were collected from 197 welders and 150 non-exposed white-collar males matched for age, sex and smoking. The serum was assayed for total protein, albumin, total antioxidant capacity, manganese superoxide dismutase, aconitase, glutathione peroxidase (GPx), heat shock protein 70, isoprostane, and reactive oxygen species (ROS). Changes caused by welding was evaluated in three groups based on exposure duration i.e., 1-10, 11-20 and 21 or more years of work. This resulted in a sample size of 142 with exposure duration of 3.91 +/- 2.95 years, 27 with exposure duration of 16.52 +/- 2.91 years, and 28 with welding exposure of 25.39 +/- 2.74 years. In addition, we investigated whether independent and combined effect of smoking and welding influenced the markers of oxidative stress. Welding was associated with increases in serum protein, GPx, aconitase, ROS generation and isoprostane levels compared to controls. The most dramatic change was a 143% increase in serum isoprostane levels with the corresponding 19% increased potential for generating ROS in welders, which was also significant in all exposure groups. Smoking, independently or in combination with welding exposure, generally was not influential in markers of oxidative stress. The results suggest that welding exposure can cause oxidative stress in workers of significant magnitude to be measured by serum biomarkers.
Keywords
Welders; Welding-industry; Shipyard-industry; Shipyard-workers; Shipyards; Occupational-diseases; Diseases; Welders-lung; Fumes; Fumigants; Blood-samples; Blood-sampling; Occupational-exposure; Demographic-characteristics; Age-factors; Sex-factors; Smoking; Exposure-levels; Exposure-assessment; Biomarkers
CODEN
PATSBB
Publication Date
20050520
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
vav1@cdc.gov
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
Abstracts
ISSN
1546-3222
NIOSH Division
HELD
Source Name
Proceedings of the American Thoracic Society. 2005 ATS International Conference, May 20-25, 2005, San Diego, California
State
WV
TOP