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Exhaled nitric oxide measurement in workers in a microwave popcorn production plant.

Authors
Akpinar-Elci-M; Stemple-KJ; Elci-OC; Dweik-RD; Kreiss-K; Enright-PL
Source
Int J Occup Environ Health 2006 Apr-Jun; 12(2):106-110
NIOSHTIC No.
20030092
Abstract
Airways obstruction in microwave-popcorn workers has been attributed to inhalation of flavoring agents. Two former workers at a microwave-popcorn plant were found by lung biopsy to have bronchiolitis obliterans. The study's aim was to determine whether exhaled nitric oxide (FENO) levels were associated with exposure levels, respiratory symptoms, or airways obstruction. A questionnaire, spirometry, and FENO measurements were completed by 135 workers. The FENO levels of workers with high flavoring exposures (n = 107) were compared with those of workers with low exposures (n = 28) and healthy external controls (n = 31). FENO levels were significantly lower in the high-exposure group (p < 0.05). There is no indication that FENO is useful as a marker of lung injury in a flavoring-exposed worker population with a substantial lung disease burden, but the finding of low FENO in the high-exposure group should not be dismissed.
Keywords
Nitrates; Oxides; Respiratory-system-disorders; Airway-obstruction; Lung-disease; Food-additives; Food-processing; Food-processing-workers; Food-processing-industry; Pulmonary-disorders; Pulmonary-function; Pulmonary-system-disorders; Spirometry; Chest-X-rays; Occupational-exposure
Contact
National Institute for Occupational Safety and Health, Division of Respiratory Diseases Studies, Field Studies Branch, Mail Stop H-2800, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
IOEHFU
CAS No.
10102-43-9
Publication Date
20060401
Document Type
Journal Article
Email Address
melci@cdc.gov
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1077-3525
NIOSH Division
DRDS
Source Name
International Journal of Occupational and Environmental Health
State
WV; OH
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