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Animal models of occupational asthma: tools for understanding disease pathogenesis.

Authors
Johnson-VJ; Luster-MI
Source
Asthma in the workplace and related conditions, third edition. Bernstein IL, Chan-Yeun M, Malo JL, Bernstein DI, eds. New York: Taylor and Francis Group, 2006 Jan; :141-159
Link
NIOSHTIC No.
20030020
Abstract
Occupational asthma is the most frequently reported occupational respiratory disease in industrialized nations, and numerous low-molecular-weight chemicals and high-molecular-weight proteins encountered in the workplace are known or suspected causative agents (1). Classical and novel animal models are being used to investigate exposure determinants, epitope identity, and the role played by the immune system in occupational asthma in order to recapitulate disease phenotype and further current understanding of its pathogenesis. Important aspects of exposure determinants that can be addressed and controlled using animal models include (i) relevant routes of exposure including respiratory and/or skin, (ii) exposure dose, (iii) exposure duration and frequency, and (iv) determination of relevant epitopes. In addition, well-defined genetics of animal models present unique opportunities for detailed investigations into pathogenic mechanisms through the use of transgenic models and antibody neutralization strategies. The data generated through the use of animal models is instrumental for risk assessment used to refine workplace exposure limits. Numerous guinea pig, rat, and mouse models of occupational asthma have been developed to address these issues. It is likely that key molecular and cellular events will be identified through the use of these models, potentially leading to new treatment modalities that may be specific for these classes of asthmogen and will aid in establishing more protective workplace exposure limits.
Keywords
Animals; Animal-studies; Models; Occupational-diseases; Diseases; Bronchial-asthma; Pathogenesis; Pathogenicity; Respiratory-system-disorders; Occupational-exposure; Occupational-health; Occupational-hazards; Skin-exposure; Exposure-levels; Exposure-assessment; Laboratory-animals; Exposure-limits
Publication Date
20060101
Document Type
Book or book chapter
Editors
Bernstein-IL; Chan-Yeung-M; Malo-JL; Bernstein-DI
Fiscal Year
2006
NTIS Accession No.
NTIS Price
ISBN No.
9780824729776
NIOSH Division
HELD
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
Asthma in the workplace and related conditions, third edition
State
WV
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