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Dose and airflow dependence of benzyl alcohol disposition on skin.

Authors
Miller-MA; Bhatt-V; Kasting-GB
Source
J Pharm Sci 2006 Feb; 95(2):281-291
NIOSHTIC No.
20029953
Abstract
The penetration of benzyl alcohol (BA) through split-thickness cadaver skin was measured in nonoccluded Franz cells placed in a fume hood. BA, dissolved in a small volume of ethanol and spiked with (14)C radiolabel, was applied to skin at nine doses ranging from 0.9 to 10600 microg/cm(2). The percentage of radioactivity penetrated after 24 h increased gradually with dose, ranging from 19.8 +/- 2.9% at the lowest dose to 29.2 +/- 3.0% at the highest. Less than 4% of the radioactivity was retained in the tissue at 24 h; the remainder was considered to be evaporated. These data and those from a previous study were analyzed in terms of a finite dose diffusion/evaporation model. The analysis showed that the increase in BA absorption with dose was consistent with a threefold increase in BA diffusivity in the stratum corneum, as its concentration increased from tracer levels to saturation. The variable diffusivity model was able to describe the combined observations from the two studies to within an rms error of 4.2% of dose. A method of estimating the diffusion model parameters independently of the experiment was found to yield good agreement with the experimentally-derived values at low and moderate doses.
Keywords
Air-flow; Mathematical-models; Models; Skin; Dose-response; Exposure-levels; Exposure-assessment; Skin-absorption
CODEN
JPMSAE
CAS No.
100-51-6
Publication Date
20060201
Document Type
Journal Article
Email Address
Gerald.Kasting@uc.edu
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007529
Issue of Publication
2
ISSN
0022-3549
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
Journal of Pharmaceutical Sciences
State
OH
Performing Organization
University of Cincinnati
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