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Petrochemical exposure and menstrual disturbances.

Authors
Thurston-SW; Ryan-L; Christiani-DC; Snow-R; Carlson-J; You-L; Cui-S; Ma-G; Wang-L; Huang-Y; Xu-X
Source
Am J Ind Med 2000 Nov; 38(5):555-564
NIOSHTIC No.
20029931
Abstract
BACKGROUND: An exploratory, cross-sectional retrospective study was conducted to examine the effects of benzene exposure on menstrual problems. METHODS: The study was based on a survey administered to over 3,000 women who worked in a large petrochemical company in Beijing, China. An abnormal menstrual cycle length (AMCL), defined as an average menstrual cycle length of greater than 35 days or less than 21 days, is the major outcome of interest. RESULTS: After 7 years of benzene exposure, the adjusted odds ratio of having AMCL for each additional 5 years of exposure was 1.71 (95% CI 1.27-2.31). Feeling stressed at work was also an important predictor. CONCLUSIONS: This study suggests a significant association of benzene exposure and perceived stress with menstrual disturbance. A prospective study is needed to confirm this finding.
Keywords
Organic-solvents; Occupational-exposure; Risk-factors; Chemical-hypersensitivity; Solvents; Analytical-methods; Exposure-assessment; Women; Humans; Reproductive-system-disorders
Contact
Sally W. Thurston, Department of Biostatistics, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115
CODEN
AJIMD8
CAS No.
71-43-2; 8006-61-9; 7439-96-5; 7783-06-4; 7664-41-7
Publication Date
20001101
Document Type
Journal Article
Email Address
sthursto@hsph.harvard.edu
Funding Amount
1168572
Funding Type
Grant
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003027
Issue of Publication
5
ISSN
0271-3586
Priority Area
Disease and Injury: Fertility and Pregnancy Abnormalities
Source Name
American Journal of Industrial Medicine
State
MA
Performing Organization
Harvard University, Boston, Massachusetts
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