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Inert multiple membrane-coated fibers predict dermal absorption of chemicals from mixtures.

Authors
Riviere-JE; Xia-X; Baynes-RE; Monteiro-Riviere-NA
Source
Toxicologist 2006 Mar; 90(1):171
NIOSHTIC No.
20029877
Abstract
Skin absorption of compounds from chemical mixtures is affected by many factors including chemical-chemical, chemical-vehicle, chemical-skin and vehicle-skin interactions; with the rate-limiting process primarily being interactions with the stratum corneum. To address this, we have developed a multiple membrane-coated fiber (MCF) approach that unlike in vitro skin systems, has the advantages of relatively high throughput. Three diverse MCFs [polydimethylsiloxane (PDMS, lipophilic), polyacrylate (PA, polarizable) and CarboWax (wax, polar)] were selected to simulate the array of molecular interactions existing in the skin/chemical mixture systems. Skin permeability coefficient (log kp) of a set of 16 diverse compounds from chemical mixtures (water, water-ethanol, water surfactant) were measured by in vitro flow through diffusion experiments and membrane/chemical mixture partition coefficients (log KMCF/Mix) were determined. Concentrations of all chemicals were assayed using GC-MS. Multiple regression analysis was used to define equations linking log kp to log KMCF/Mix for the three MCFs across the three vehicle systems. Significant correlation equations were defined for each vehicle exposure: water - R2=0.96; 50% ethanol - R2=0.91; and 1% SLS - R2=0.86. Differences in equations across vehicles probably reflect mixture-skin interactions. These studies demonstrate that dermal absorption of a diverse series of compounds can be estimated from data collected in three inert fibers which reflect the physicochemical diversity of interactions seen when chemicals partition into the stratum corneum.
Keywords
Skin-absorption; Chemical-analysis; Skin; In-vitro-studies; In-vivo-studies
Publication Date
20060301
Document Type
Abstract
Funding Amount
746428
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007555
Issue of Publication
1
ISSN
1096-6080
Priority Area
Work Environment and Workforce: Mixed Exposures
Source Name
The Toxicologist. Society of Toxicology 45th Annual Meeting and ToxExpo, March 5-9, 2006, San Diego, California
State
NC
Performing Organization
North Carolina State University, Raleigh, North Carolina
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