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Use of a job-exposure matrix to assess occupational exposures in relation to birth defects.

Authors
Louik-C; Frumkin-H; Ellenbecker-MJ; Goldman-RH; Werler-MM; Mitchell-AA
Source
J Occup Environ Med 2000 Jul; 42(7):693-703
NIOSHTIC No.
20029850
Abstract
Accurate exposure assessment remains a challenge in occupational epidemiology. We evaluated one approach, use of a job-exposure matrix (JEM), by applying the National Institute for Occupational Safety and Health (NIOSH) JEM to a large case-control birth defects study that included parental occupation information. We investigated the JEM exposure predictions in several ways and found that for a substantial proportion of the parents in the birth defects study, the JEM yielded either no exposure data or nonsense predictions. Among exposure predictions that were plausible, most were of low probability. The high probability exposure predictions were statistically unstable, and neither low nor high probability exposure predictions were reliable. There was considerable discrepancy between the JEM predictions and expert assessments for five exposures of interest. Application of the NIOSH JEM to the birth defects study database (and probably other databases as well) does not provide a useful means of assessing occupational exposures.
Keywords
Reproductive-system-disorders; Reproductive-hazards; Risk-analysis; Epidemiology; Occupational-exposure; Exposure-levels; Exposure-methods
Contact
Carol Louik, ScD, Slone Epidemiology Unit, 1371 Beacon Street, Brookline, MA 02446
CODEN
JOEMFM
Publication Date
20000701
Document Type
Journal Article
Email Address
clouik@slone.bu.edu
Funding Amount
518231
Funding Type
Grant
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02598
Issue of Publication
7
ISSN
1076-2752
Priority Area
Reproductive-system-disorders
Source Name
Journal of Occupational and Environmental Medicine
State
MA
Performing Organization
Boston University, Boston, Massachusetts
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