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Regulated workplace ketones and their interference in the PFBHA method for aldehydes.

Authors
Lin-YW; Hee-SS
Source
Appl Occup Environ Hyg 2000 Nov; 15(11):855-862
NIOSHTIC No.
20029848
Abstract
Ketones are the major positive interferences for an aldehyde dynamic air sampler that consists of 200-mg 20 percent (w/w) O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) on Tenax TA contained in a Pyrex tube 7-mm OD, 5-mm ID, and 70-mm in length, that utilizes a personal battery-powered pump at 10-50 mL/min. The ketone O-oxime derivatives were synthesized to allow absolute quantitation of O-oximes formed during sampling. Wet spiking allowed ketone recoveries to be found. Ketone vapors of known concentrations were generated statically in Tedlar gas bags. The O-oximes were desorbed with hexane, and an aliquot injected for gas chromatographic analysis on a nonpolar capillary column with mass spectrometric or electron capture detection. Gas phase recoveries up to 200 ppm-hour loadings exceeded 75 percent at 25 degrees C for chloroacetone, cyclohexanone, diacetone alcohol, diethyl ketone, dipropyl ketone, ethyl butyl ketone, methyl amyl ketone, methyl butyl ketone, 2-methylcyclohexanone, methyl ethyl ketone, methyl isobutyl ketone, methyl isopropyl ketone, and methyl propyl ketone. The recoveries for acetophenone, 2-chloroacetophenone, and ethyl amyl ketone were lower than 75 percent, and were caused by steric hindrance. Sampling for both aldehydes and ketones is recommended at 10 mL/min for TLV concentrations.
Keywords
Air-sampling; Air-sampling-techniques; Sampling-methods; Workplace-monitoring; Gas-chromatography; Aldehydes; Exposure-limits; Mass-spectrometry
CODEN
AOEHE9
CAS No.
5470-11-1; 75-07-0; 111-30-8; 107-20-0; 4170-30-3; 50-00-0; 98-01-1
Publication Date
20001101
Document Type
Journal Article
Funding Amount
515055
Funding Type
Grant
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003120
Issue of Publication
11
ISSN
1047-322X
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
Applied Occupational and Environmental Hygiene
State
CA
Performing Organization
University of California Los Angeles, Los Angeles, CA
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