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Luteinizing hormone in premenopausal women may stimulate uterine leiomyomata development.

Authors
Baird-DD; Kesner-JS; Dunson-DB
Source
J Soc Gynecol Invest 2006 Feb; 13(2):130-135
NIOSHTIC No.
20029756
Abstract
Human chorionic gonadotropin (hCG) has proliferative effects on uterine smooth muscle and leiomyoma tissue in vitro. We hypothesized that luteinizing hormone (LH) would have the same effect by activating the LH/hCG receptor, and it would follow that premenopausal women with higher basal LH levels would be more likely to have leiomyomata. Randomly selected women, aged 35 to 49 years, from a prepaid health plan were screened for leiomyomata with pelvic ultrasound. Urine samples collected during the first or last 5 days of the menstrual cycle were analyzed for LH by immunofluorometric assay, and concentrations were corrected for creatinine (n = 523). Logistic regression and Bayes analyses were used to evaluate the association of LH with presence and size of leiomyomata, adjusting for age, and other risk factors. Women with higher LH were more likely to have leiomyomata (adjusted odds ratios for second and third tertiles were 1.7 and 2.0 compared with lower tertile; 95% confidence intervals, 1.0 to 2.7 and 1.2 to 3.4, respectively). The association was stronger for large leiomyomata. Bayes analyses designed to estimate LH effects on tumor onset separately from tumor growth showed significantly accelerated tumor onset but little evidence of effects on tumor growth. Age, an independent risk factor for leiomyomata, was not affected by inclusion of LH in the logistic models. As hypothesized, women with higher LH were more likely to have leiomyomata, but this did not explain the age-related increase in leiomyomata during perimenopausal ages. Determining whether LH is causal or a marker for susceptibility will require further research.
Keywords
Hormones; Hormone-activity; Demographic-characteristics; Sex-factors; Age-factors; Age-groups; Urinalysis; Menstrual-disorders; Women; Risk-factors; Risk-analysis
Contact
Donna Baird, PhD, Epidemiology Branch, MD A3-05, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709
CODEN
JSGIED
Publication Date
20060201
Document Type
Journal Article
Email Address
baird@niehs.nih.gov
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1071-5576
NIOSH Division
DART
Priority Area
Disease and Injury: Fertility and Pregnancy Abnormalities
Source Name
Journal of the Society for Gynecologic Investigation
State
OH; NC
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