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Interpretation of the trace metal analysis profile for patients ccupationally exposed to metals.

Authors
Guidotti-TL; Audette-RJ; Martin-CJ
Source
Occup Med 1997 Nov; 47(8):497-503
NIOSHTIC No.
20029657
Abstract
Trace element profile analysis detects and quantifies the presence of several metals simultaneously at low concentrations in the body. In occupational medicine, it may be used to monitor exposure or to evaluate suspected toxicity. Clinical interpretation is often difficult because, with the exception of lead and possibly cadmium, there is little firm information on toxicity thresholds. For these tests, the reference ranges typically reflect low levels of exposure in the general population and it is expected that workers handling metals in occupations such as welding and industries such as steelmaking will have higher levels. Interpretation requires some knowledge of the toxicokinetics of the metal of interest and the preferred medium for analysis for each: serum, whole blood or urine (preferably 24-hour collection). Trends are often more informative than concentrations at one time. Trace element values are reported together with a reference range which must be distinguished from the normal range of other clinical tests. As a practical matter, the greatest interpretation problems tend to be found with manganese because serum levels have a poor correlation with both recent exposure and neurological symptoms. Molybdenum and vanadium are often found to be elevated among workers exposed to metals who show no evidence of clinical illness. Interpretation of the trace element profile analysis overall when an elevation occurs generally requires close attention to the pattern of elevation, clinical context, absolute and relative magnitude of the elevation and knowledge of the exposure history.
Keywords
Occupational-exposure; Metals; Trace-metals; Trace-analysis; Occupational-medicine; Environmental-health-monitoring; Metallurgy
CODEN
OCMEE8
Publication Date
19971101
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T01-CCT-310455
Issue of Publication
8
ISSN
0962-7480
Source Name
Occupational Medicine
State
WV
Performing Organization
West Virginia University, School of Medicine, Institute of Occupational and Environmental Health, Morgantown, West Virginia
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