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Induction of ferritin and lipid peroxidation by coal samples with different prevalence of coal workers' pneumoconiosis: role of iron in the coals.

Authors
Zhang-Q; Huang-X
Source
Am J Ind Med 2002 Sep; 42(3):171-179
NIOSHTIC No.
20029612
Abstract
BACKGROUND: Differences in levels of bioavailable iron (BAI) in coal may be responsible for the observed regional differences in the prevalence and severity of coal workers' pneumoconiosis (CWP). METHODS: Twenty-nine coal samples from three coal mine regions were tested in human lung epithelial Type II A549 cells. They were from Utah (UT), West Virginia (WV), and Pennsylvania (PA) with a prevalence of CWP of 4, 10, and 26%, respectively. RESULTS: Low molecular weight (LMW) chelators bound iron, a fraction of BAI in the cells released from coals, ferritin, and lipid peroxidation were significantly higher in cells treated with various coals than in control cells, with an increasing order of UT < WV < PA, in parallel to the prevalence of CWP in these coal mine regions. Deferoxamine (DFO), a specific iron chelator, was used to distinguish effects of BAI from those of other transition metals. Our results indicate that BAI in the coals of WV and UT is the main metal species in inducing ferritin and lipid peroxidation. In contrast, biological effects of PA coals are not only from BAI, but from other transition metals as well. CONCLUSIONS: Based on a large number of coal samples from various seams, the findings of this study provide further evidence that metals, particularly iron, play important roles in coal dust-induced cellular damage, ultimately leading to the development of CWP and contributing to the regional differences in the prevalence of the disease.
Keywords
Coal-workers; Coal-mining; Coal-miners; Lung-disease; Diseases; Coal-dust; Iron-compounds; Pulmonary-system-disorders; Respiratory-system-disorders; Occupational-diseases; Occupational-exposure; Pneumoconiosis; Author Keywords: ferritin; iron; lipid peroxidation; coal workers' pneumoconiosis
Contact
Department of Environmental Medicine, New York University School of Medicine, New York, New York 10016
CODEN
AJIMD8
CAS No.
471-34-1
Publication Date
20020901
Document Type
Journal Article
Funding Amount
638746
Funding Type
Grant
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003561
Issue of Publication
3
ISSN
0271-3586
Source Name
American Journal of Industrial Medicine
State
NY
Performing Organization
New York University Medical Center, New York, New York
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