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Vibration injury damages arterial endothelial cells.

Authors
Curry-BD; Bain-JL; Yan-JG; Zhang-LL; Yamaguchi-M; Matloub-HS; Riley-DA
Source
Muscle Nerve 2002 Apr; 25(4):527-534
NIOSHTIC No.
20029485
Abstract
Prolonged exposure to hand-transmitted vibration can cause debilitating neural and vascular dysfunction in humans. It is unclear whether the pathophysiology involves simultaneous or sequential injury of arteries and nerves. The mechanism of vibration injury was investigated in a rat tail model, containing arteries and nerves structurally similar to those in the human hand. Tails were selectively vibrated for 1 or 9 days with the remainder of the animal at rest. One vibration bout of 4 h/day, 60 HZ, 5 g (49 m/s(2)) acceleration, injured endothelial cells. Injury was signaled by elevated immunostaining for NFATc3 transcription factor. Electron microscopy revealed that vibration for 9 days produced loss and thinning of endothelial cells, with activated platelets coating the exposed subendothelial tissue. Endothelial cells and arterial smooth muscle cells contained double membrane-limited, swollen processes indicative of vasoconstriction-induced damage. Laser doppler surface recording demonstrated that 5 min of vibration significantly diminished tissue blood perfusion. These findings indicate that early injury involves vasoconstriction and denuding of the arterial endothelium. Copyright 2002 Wiley Periodicals, Inc.
Keywords
Neuropathology; Injuries; Vibration; Vibration-exposure; Vibration-effects; Neurovascular-disorders; Humans; Laboratory-animals; Animals; Animal-studies
Contact
Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226
CODEN
MUNEDE
Publication Date
20020401
Document Type
Journal Article
Funding Amount
922402
Funding Type
Grant
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003493
Issue of Publication
4
ISSN
0148-639X
Priority Area
Other Occupational Concerns
Source Name
Muscle & Nerve
State
WI
Performing Organization
Medical College of Wisconsin, Milwaukee, Wisconsin
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